Optimization of correction of sleep, speech and cognitive disorders in children due to perinatal CNS injury
O. Yu. Sukhonosova, S. M. Korenev, T. M. Prykhodko, V. V. Salnikova, V. M. Petrenko, M. V. Hekova
Sukhonosova Olga Yuriivna
Kharkiv Medical Academy of Postgraduate Education, Ukraine, 61176, Kharkiv, 58, Amosova str., vladol2017a@gmail.com ORCID: 0000-0002-1205-4896
Korenev Sergey Mykolayovych
Kharkiv Medical Academy of Postgraduate Education, Ukraine, 61176, Kharkiv, 58, Amosova str.
Prikhodko Tetyana Mykhailivna
Communal non-commercial enterprise "City Children's Hospital No. 5" KhMR, Ukraine, 61099, Kharkiv, 43, Tankopia str.
Salnikova Vladlena Viktorivna
Communal non-commercial enterprise "City Children's Hospital No. 5" KhMR, Ukraine, 61099, Kharkiv, 43, Tankopia str.
Petrenko Victoria Nikolaevna
Communal non-commercial enterprise "City Children's Hospital No. 5" KhMR, Ukraine, 61099, Kharkiv, 43, Tankopia str.
Hekova Marina Vyacheslavivna
Communal non-commercial enterprise "City Children's Hospital No. 5" KhMR, Ukraine, 61099, Kharkiv, 43, Tankopia str.
The problem of perinatal pathology, including the central nervous system (CNS), remains one of the urgent medical issues for a long time. According to the State Statistics Committee of Ukraine, conditions arising in the perinatal period, make 18% and take a second place in the morbidity structure of children under 1.5 years of age [1]. Signs of damage to the central nervous system are registered in 65-75% of children in the neonatal period. Neurological pathology occurs in about 30% of children at the age of 1 year. The formation of language, the formation of intelligence, and the development of static-kinetic functions take place in the first years of a child's life. In older children, the incidence of neurological disorders of perinatal genesis is quite high and the indicator is constantly increasing [2].
Therefore, timely diagnosis and treatment of neurological diseases in childhood affect the entire future life of a person, his physical and mental state and social adaptation.
In modern life, there is an increasing influence of social and environmental factors on the development and activity of the child, which, in combination with the increase in the prevalence of perinatal lesions of the central nervous system, are the reasons for the increase in mild forms of cerebral pathology. Cerebral pathology is one of the most common neuropsychological disorders in childhood, and is manifested by age immaturity of certain high mental functions and their disharmonious development.
Children with this pathology experience significant difficulties in learning and social adaptation. These disorders are characterized by learning difficulties, inattention, poor logical thinking, memory and attention disorders, and disorders of motor skills such as poor orientation, dysarthria, clumsiness, impulsivity, irritability, hyperactivity, sleep disorders [3].
One of the urgent tasks of children's neurology is the search for effective criteria for early diagnosis and prediction of neuropsychological disorders in different age periods, the development of differentiated rehabilitation programs for children from "risk groups" of children's neurological diseases and treatment protocols.
Phytotherapy is well tolerated and it is successfully used for sleep disorders, increased anxiety and irritability, impulsivity, aggressiveness, hyperactivity, anxiety, mood swings, depression, and social dysfunction. According to sociological studies, plant-based products used for the treatment and prevention of various diseases make about 40%.
The population prefers treatment with herbs and traditional remedies of natural origin [4].
In order to correct CNS disorders in children with the consequences of perinatal injury, we considered the possibility of using the herbal complex Anantavati® Kids, which includes extracts of Withania somnifera and Bacopa monnieri.
These phytocomponents have become widespread in world clinical practice and have polymodal pharmacodynamics [5–8].
Due to components, such as cytoindosides VII and VIII, vananolides and steroid lactones (withanone, withaferin), alkaloids (ashwagandolin, isopellethrine, anaferin) Withania somnifera exerts anti-stress, antioxidant, neuromodulating effects on GABA and GABAergic neuromediation and reduces the level of the stress hormone cortisol. Activation of GABAergic processes is necessary to ensure falling asleep and normalization of the physiological structure of sleep [7].