NEW POSSIBILITIES IN THE TREATMENT OF PATIENTS WITH DISCIRCULATORY ENCEPHALOPATHY - FOCUS ON NERVE GROWTH FACTOR
T.S. Mishchenko, V.V. Sokolik, V.M. Mishchenko, I.V. Dariy
Summary
This study has shown the results of research on the role of neuronal growth factors in the development and progression of cognitive and psychoemotional disorders.
The peculiarities of Bacopa Monier and Ginkgo Biloba influence on structural and functional changes of the brain in the experiment and in certain groups of patients have been shown.
The results of the use of phytocomplex Memostim® (fixed combination of Bacopa Monier - 150 mg and Ginkgo Biloba - 120 mg) in 30 patients with II stage dyscirculatory encephalopathy (DE), caused by atherosclerosis and arterial hypertension are described.
The control group involved 30 patients with II stage DE who were not treated with Memostim®. After 3 months of using Memostim® a decrease in the frequency and severity of cephalic, vestibulo-atactic and asthenic syndromes was observed in patients.
There was a significant improvement in cognitive functions (MoSA scale) and psycho-emotional state of patients. There was a significant improvement in operations and attention (by 22% relative to baseline, p <0.05) and the overall score on the test (+ 8%, p> 0.05).
The general tendency to improve visual-constructive functions, memory, speech, executive functions, abstract thinking and orientation has been identified.
Similar results of the effect of Memostim® on cognitive functions were obtained from FAB questionnaire. According to the results of the survey of patients on the scale of quality of life, a significant positive dynamics of the integrative index (statistically significant increase by 31%), index of psychological well-being (increase by 32%), self-satisfaction (by 28%), indicators of physical well-being (by 18%) after 3 months of using Memostim® has been established.
The level of neuronal growth factor (β-NGF) has significantly increased (by 67%). The analysis of the obtained data testifies to the effectiveness and safety of Memostim® when used in patients with DE.
Thus, the obtained data demonstrate the profound effect of Memostim® on the symptoms of cognitive and psychoemotional disorders in patients with DE, due to increased NGF levels on the background of the course.
Introduction
The armed conflict in the East of Ukraine has become a powerful impetus to the development of the series of stress-induced states among both military and civilian population. According to information of United Nations, dated July 10, 2015, 6764 people have become the victims of the armed conflict
in Ukraine (including civilians), 16,877 people have been injured and the number of temporarily displaced persons has exceeded 2.3 million (United nations office for the coordination of humanitarian affairs, 2015). As the practice shows, not only people affected during the military actions, but also their relatives need an urgent psychological and psychiatric care.
Staying in the zone of the anti-terrorist operation (ATO) contributes to the formation of different types of post-traumatic stress disorders, where anxiety and depressive disorders dominate in psychopathological structure. Soldiers used to reside in high-risk conditions that require active and decisive action. Soldiers were accustomed to constantly stay in high-risk conditions that require active and decisive action.
Getting back to a peaceful life, they continue to live on high alert; as a result the psychopathological disorders are developed.
These psychopathological states include anxiety and depressive disorders of different types and severity, as well as socially disadapted behavior (different kinds of addiction, aggressive behavior and suicide). We note that neuro-psychiatric disorders were revealed in large quantities in soldiers and civilians during the war in Vietnam, Afghanistan, Iraq and Chechnya. On the experience of these wars, the studies of stressful conditions have been already conducted.
And the results showed the long duration of their course and severity of the medical and social consequences.