Effect of omega-3 fatty acid on atrial fibrillation

Based on results from four randomized clinical trials, the reception of omega-3 fatty acids is associated with a dose-dependent risk of atrial fibrillation.

The most recent study evaluating this link, VITAL-RHYTHM, has found that the use of low doses of omega-3 fatty acids or vitamin D supplements did not appear to have any effect on the risk of atrial fibrillation events. In the STRENGTH and REDUCE-IT studies, which evaluated high doses (4 grams per day) of omega-3 fatty acids in patients with heart disease, there was a statistically significant increase in the risk of atrial fibrillation compared to the control group. In OMEMI study, in elderly patients with recent myocardial infarction, the lower dose (1.8 g per day) of omega-3 fatty acids also has shown an increased risk. The latest study, VITAL-RHYTHM, evaluated the minimum dose of omega-3 fatty acids (820 mg per day). As the information is new, healthcare professionals recommend to inform patients about the risk of atrial fibrillation.